DIG - a system for gene annotation and functional discovery

نویسندگان

  • Mark DeLong
  • Guang Yao
  • Quanli Wang
  • Adrian Dobra
  • Esther P. Black
  • Jeffrey T. Chang
  • Andrea Bild
  • Mike West
  • Joseph Nevins
  • Holly Dressman
چکیده

SUMMARY We describe a database and information discovery system named DIG (Duke Integrated Genomics) designed to facilitate the process of gene annotation and the discovery of functional context. The DIG system collects and organizes gene annotation and functional information, and includes tools that support an understanding of genes in a functional context by providing a framework for integrating and visualizing gene expression, protein interaction and literature-based interaction networks.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Identification of Prognostic Genes in Her2-enriched Breast Cancer by Gene Co-Expression Net-work Analysis

Introduction: HER2-enriched subtype of breast cancer has a worse prognosis than luminal subtypes. Recently, the discovery of targeted therapies in other groups of breast cancer has increased patient survival. The aim of this study was to identify genes that affect the overall survival of this group of patients based on a systems biology approach. Methods: Gene expression data and clinical infor...

متن کامل

Study of Gene Expression Signatures for the Diagnosis of Pediatric Acute Lymphoblastic Leukemia (ALL) Through Gene Expression Array Analyses

Background: Acute lymphoblastic leukemia (ALL) as the most common malignancy in children is associated with high mortality and significant relapse. Currently, the non-invasive diagnosis of pediatric ALL is a main challenge in the early detection of patients. In the present study, a systems biology approach was used through network-based analysis to identify the key candidate genes related to AL...

متن کامل

Fuzzy Neighbor Voting for Automatic Image Annotation

With quick development of digital images and the availability of imaging tools, massive amounts of images are created. Therefore, efficient management and suitable retrieval, especially by computers, is one of themost challenging fields in image processing. Automatic image annotation (AIA) or refers to attaching words, keywords or comments to an image or to a selected part of it. In this paper,...

متن کامل

A CAD System Framework for the Automatic Diagnosis and Annotation of Histological and Bone Marrow Images

Due to ever increasing of medical images data in the world’s medical centers and recent developments in hardware and technology of medical imaging, necessity of medical data software analysis is needed. Equipping medical science with intelligent tools in diagnosis and treatment of illnesses has resulted in reduction of physicians’ errors and physical and financial damages. In this article we pr...

متن کامل

Design and Construction of ctxB-gfp-stxB Gene Cassette and Investigation of Its Expression in E. coli Bl21 (DE3)

Background & Objective: In order to enhance the expression of soluble proteins and facilitate their purification and development of multi-functional polypeptide , chimerical recombinant proteins have been invented . The purpose of this study was to construct ctxB-gfp-stxB gene cassette to measure the uptake and excretion of chimerical antigen in future studies.   Materials & Methods: After prep...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Bioinformatics

دوره 21 13  شماره 

صفحات  -

تاریخ انتشار 2005